245 research outputs found
âAnother story for another time": The many-strandedness of a Jewish woman's storytelling tradition
This article is a cursory outline description of the Marks-Khymberg family tradition of Anglo-Dutch Jewish oral narrative, in its context, culminating in a preliminary analysis of one sub-cycle of tales drawn from the family repertoire.N/
Storytelling revivalism in England and Wales : history, performance and interpretation.
This study discusses the storytelling movement in England and Wales as an
example of the traditional arts "revival." "Revivals" are qualitatively different
from mature traditions, but this distinction eludes theorisation. This creates
shortcomings in the literature, which are identified and discussed. It is
concluded that mature traditions and "revivals" are both subcategories of
traditional milieu. The "revival" is distinguished, firstly, by its attenuated
diachronic chains of transmission and synchronic bonds of social cohesion,
resulting in a loss of deep aesthetic consensus in the participant group; and,
secondly, by its self-traditionalisation: its selfconscious self-presentation as a
traditional form socioculturally opposed to a traditionless mainstream
modernity. The "revival" is therefore often understood as a nostalgic and
symbolic re-enactment of desired sociocultural conditions.
The study is an inductive, transparent consideration of storytelling revivalism
in England and Wales in the light of this preliminary conclusion, considering
three issues: the history of the movement; the whole-group performance of
storytelling events; and emic interpretations and understandings of
involvement, elicited in interview. The evidence is that storytelling revivalism
is part of a long-lived appropriative process transcending sociocultural
distinctions; that its performative idioms do not express but mediate -
eventually, undermine - its iconoclastic separateness from modernity,
integrating the formally "revived" form into the informal mainstream; and that
interviews demonstrated nostalgic sociocultural beliefs to be contingent and of
secondary importance to aesthetic experience. In conclusion, revivalistic
communities indulge selfconscious self-traditionalisation sparingly and
reluctantly. Emically, it is an uninteresting implication or a necessary
cognitive and behavioural stopgap facilitating a deeper experiential familiarity
with the form itself "Revival," although occupying an intellectually
enfranchised milieu, is properly a nascent non-intellectual, aesthetic and social
form. This conclusion overturns the preliminary conclusion, and suggests the
general fallaciousness of assuming that cultural forms are primarily coded
representations of sociocultural conditions
The Free Will Theorem
On the basis of three physical axioms, we prove that if the choice of a
particular type of spin 1 experiment is not a function of the information
accessible to the experimenters, then its outcome is equally not a function of
the information accessible to the particles. We show that this result is
robust, and deduce that neither hidden variable theories nor mechanisms of the
GRW type for wave function collapse can be made relativistic. We also establish
the consistency of our axioms and discuss the philosophical implications.Comment: 31 pages, 6figure
Existential Contextuality and the Models of Meyer, Kent and Clifton
It is shown that the models recently proposed by Meyer, Kent and Clifton
(MKC) exhibit a novel kind of contextuality, which we term existential
contextuality. In this phenomenon it is not simply the pre-existing value but
the actual existence of an observable which is context dependent. This result
confirms the point made elsewhere, that the MKC models do not, as the authors
claim, ``nullify'' the Kochen-Specker theorem. It may also be of some
independent interest.Comment: Revtex, 7 pages, 1 figure. Replaced with published versio
University for the Creative Arts staff research 2011
This publication brings together a selection of the Universityâs current research. The contributions foreground areas of research strength including still and moving image research, applied arts and crafts, as well as emerging fields of investigations such as design and architecture. It also maps thematic concerns across disciplinary areas that focus on models and processes of creative practice, value formations and processes of identification through art and artefacts as well as cross-cultural connectivity. Dr. Seymour Roworth-Stoke
Young people today: news media, policy and youth justice
The new sociology of childhood sees children as competent social agents with important contributions to make. And yet the phase of childhood is fraught with tensions and contradictions. Public policies are required, not only to protect children, but also to control them and regulate their behaviour. For children and young people in the UK, youth justice has become increasingly punitive. At the same time, social policies have focused more on children's inclusion and participation. In this interplay of conflict and contradictions, the role the media play is critical in contributing to the moral panic about childhood and youth. In this article, we consider media representations of âantisocialâ children and young people and how this belies a moral response to the nature of contemporary childhood. We conclude by considering how a rights-based approach might help redress the moralised politics of childhood representations in the media
mRNA therapy corrects defective glutathione metabolism and restores ureagenesis in preclinical argininosuccinic aciduria
The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and a systemic phenotype coinciding with neurocognitive impairment and chronic liver disease. Here, we describe the dysregulation of glutathione biosynthesis and upstream cysteine utilization in ASL-deficient patients and mice using targeted metabolomics and in vivo positron emission tomography (PET) imaging using ( S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG). Up-regulation of cysteine metabolism contrasted with glutathione depletion and down-regulated antioxidant pathways. To assess hepatic glutathione dysregulation and liver disease, we present [18F]FSPG PET as a noninvasive diagnostic tool to monitor therapeutic response in argininosuccinic aciduria. Human hASL mRNA encapsulated in lipid nanoparticles improved glutathione metabolism and chronic liver disease. In addition, hASL mRNA therapy corrected and rescued the neonatal and adult Asl-deficient mouse phenotypes, respectively, enhancing ureagenesis. These findings provide mechanistic insights in liver glutathione metabolism and support clinical translation of mRNA therapy for argininosuccinic aciduria. </p
Operation Moonshot: rapid translation of a SARS-CoV-2 targeted peptide immunoaffinity liquid chromatography-tandem mass spectrometry test from research into routine clinical use
OBJECTIVES: During 2020, the UK's Department of Health and Social Care (DHSC) established the Moonshot programme to fund various diagnostic approaches for the detection of SARS-CoV-2, the pathogen behind the COVID-19 pandemic. Mass spectrometry was one of the technologies proposed to increase testing capacity. METHODS: Moonshot funded a multi-phase development programme, bringing together experts from academia, industry and the NHS to develop a state-of-the-art targeted protein assay utilising enrichment and liquid chromatography tandem mass spectrometry (LC-MS/MS) to capture and detect low levels of tryptic peptides derived from SARS-CoV-2 virus. The assay relies on detection of target peptides, ADETQALPQRK (ADE) and AYNVTQAFGR (AYN), derived from the nucleocapsid protein of SARS-CoV-2, measurement of which allowed the specific, sensitive, and robust detection of the virus from nasopharyngeal (NP) swabs. The diagnostic sensitivity and specificity of LC-MS/MS was compared with reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) via a prospective study. RESULTS: Analysis of NP swabs (n=361) with a median RT-qPCR quantification cycle (Cq) of 27 (range 16.7-39.1) demonstrated diagnostic sensitivity of 92.4% (87.4-95.5), specificity of 97.4% (94.0-98.9) and near total concordance with RT-qPCR (Cohen's Kappa 0.90). Excluding Cq>32 samples, sensitivity was 97.9% (94.1-99.3), specificity 97.4% (94.0-98.9) and Cohen's Kappa 0.95. CONCLUSIONS: This unique collaboration between academia, industry and the NHS enabled development, translation, and validation of a SARS-CoV-2 method in NP swabs to be achieved in 5Â months. This pilot provides a model and pipeline for future accelerated development and implementation of LC-MS/MS protein/peptide assays into the routine clinical laboratory
Contributions to Drug Resistance in Glioblastoma Derived from Malignant Cells in the Sub-Ependymal Zone
Glioblastoma (GB), the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of GB patients. Histological analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supra-maximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into GB growth dynamics, with implications for understanding and limiting treatment resistance
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